Assuming you mixed one 10 mg vial of PT-141 with 2 mL of bacteriostatic water, the concentration is:
- 10 mg รท 2 mL = 5 mg/mL
On a U-100 insulin syringe:
- 100 IU = 1 mL
- Therefore, 1 mL contains 5 mg
- So 1 mg = 0.2 mL = 20 IU (20 units)
Many people in peptide communities talk about 1 mg because it may reduce side effects like nausea, but the best-supported dose in clinical studies is actually 1.75 mg, not 1 mg.
- [Certain] The FDA-approved dose of bremelanotide (PT-141, marketed as Vyleesi) is 1.75 mg injected subcutaneously as needed, typically at least 45 minutes before sexual activity. It should not be used more than once in 24 hours or more than 8 times per month.
- [Likely] In real-world practice, some clinicians start patients at 1 mg to assess tolerability, especially because nausea is a common side effect, and then increase if needed.
For your specific reconstitution (10 mg mixed with 2 mL bacteriostatic water):
- 1.0 mg = 20 IU (20 units)
- 1.5 mg = 30 IU
- 1.75 mg = 35 IU (the FDA-approved dose)
- 2.0 mg = 40 IU